منابع مشابه
Herpes viruses hedge their bets.
Static latency is the hallmark of all herpes viruses. The varicella zoster virus, for instance, causes varicella (chickenpox), and after a latent phase of between 5 and 40 years, it can give rise to herpes zoster (shingles). This latency and the subsequent reactivation has intrigued and puzzled virologists. Although several factors have been suggested, it is unknown what triggers reactivation. ...
متن کاملHerpes Simplex and Pseudorabies Viruses
many must be the result of using impure systems and of secondary effects or else they are the product of a multiplicity of phenomena with similar end results. Dr. Vilcek is a splitter; he gives the impression that no unifying principle exists in the interferon system, but that there are several physically diverse interferons produced by the same cell and that cells may be induced to produce the...
متن کاملDesigning herpes viruses as oncolytics
Oncolytic herpes simplex virus (oHSV) was one of the first genetically-engineered oncolytic viruses. Because herpes simplex virus (HSV) is a natural human pathogen that can cause serious disease, it is incumbent that it be genetically-engineered or significantly attenuated for safety. Here we present a detailed explanation of the functions of HSV-1 genes frequently mutated to endow oncolytic ac...
متن کاملInvestigation of cytomegalovirus and human herpes viruses 6 and 7 as possible causative antigens in psoriasis.
Psoriasis is probably a T-cell-mediated autoimmune disease. Infectious models of autoimmune diseases have been proposed and in psoriasis, it has been suggested that there may be molecular mimicry between streptococcal antigens and epidermal keratins. The immunological profile of stable psoriasis plaques suggests, however, that viral antigens may be important. We investigated, using polymerase c...
متن کاملHerpes Group Viruses and HIV Infection
the name herpes comes from the greek herpein—“to creep.” Members of the Herpesviridae family have been identified in a variety of animals and they all share certain features, including an ability to establish latency following primary infection, as well as a potential to reactivate and cause further disease. Herpesviruses have large genomes and contain approximately 35 virion genes—all of which...
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ژورنال
عنوان ژورنال: HIV Medicine
سال: 2011
ISSN: 1464-2662
DOI: 10.1111/j.1468-1293.2011.00944_7.x